I - CARVEDILOL 1) Mechanisms and clinical effects Nebivolol is a novel beta-blocker with both a greater degree of selectivity for beta-1 adrenergic receptors than other agents in this class and an ability to stimulate endothelial nitric oxide production, leading to vasodilation and other potential clinical effects.Carvedilol is a non-selective beta-blocker with additional alpha1-blocking and antioxidant activities.Recently, third generation, vasodilating, beta-blockers were introduced into practice. They differ, though, in beta-selectivity, vasodilation properties, and other ancillary features.
Beta-adrenergic receptor blockers play an important role in the management of cardiovascular disease, including hypertension, ischemic heart disease and chronic heart failure.
